Lower infection risk
The needle does not pass through the rectum, reducing the chance of infection.
Transperineal Prostate Biopsy
What is a Transperineal Prostate Biopsy?
A transperineal prostate biopsy is a diagnostic procedure that takes small tissue samples from the prostate using a biopsy needle guided by ultrasound imaging. Unlike a transrectal biopsy, the needle passes through the perineum rather than the rectum, helping reduce the risk of infection while providing excellent access to the entire prostate.
A specialist laboratory analyses the tissue samples to determine whether prostate cancer or other prostate conditions are present.
What are the Benefits of a Transperineal Biopsy?
Improved accuracy
Better access to all regions of the prostate, including areas that can be difficult to reach.
Ultrasound-guided sampling
Targeted and systematic sampling helps improve diagnostic accuracy.
Day-case procedure
Most patients are able to go home on the same day.
What are the Risks and Possible Side Effects?
A transperineal prostate biopsy is generally well tolerated, but like any medical procedure, it can have temporary side effects. Common side effects include;
- Blood in the urine for a few days
- Blood in the semen for several weeks
- Mild bruising or discomfort around the biopsy area
- Temporary difficulty passing urine in some patients
How Should I Prepare for the Biopsy?
Before your appointment
Lets understand the types of Transperineal Prostate Biopsy
Local Anaesthetic Transperineal Biopsy
Performed while you are awake using local anaesthetic to numb the biopsy area.
- Outpatient procedure.
- Comfortable local anaesthetic.
- Quick recovery and same-day discharge.
Stepper-Guided Transperineal Biopsy
Uses a stepper stabiliser with ultrasound guidance for precise, systematic sampling of the prostate.
- Highly accurate needle positioning.
- Suitable for systematic and targeted biopsies.
- May be performed under local or general anaesthetic.
What Happens After the Biopsy?
After the procedure, you will be monitored for a short period before returning home.
Drink plenty of fluids during the first 24–48 hours.
Avoid strenuous exercise or heavy lifting for one to two days.
Mild blood in the urine or semen is expected for a short period.
In most cases, patients can safely return to their regular daily activities within one to two days.
When Will I Get My Results?
A specialist pathologist examines your biopsy samples. Results are typically ready within one to two weeks after the procedure. At your follow-up appointment, your urologist will explain:
- Whether cancer was found.
- The biopsy findings.
- Any further tests or treatment recommendations.
What are the Symptoms to Notice After the Biopsy?
- Fever or chills
These may indicate an infection.
- Difficulty or inability to pass urine
This requires prompt medical assessment.
- Heavy bleeding or large blood clots
Seek urgent medical advice.
- Severe or worsening pain
Especially if it does not improve after the procedure.
Where Can I Get More Information?
Our consultant urologists can provide more information about transperineal prostate biopsy, prostate cancer diagnosis, and your treatment options.
Mr Amar Mohee
Consultant Urological Surgeon from Manchester
Mr Marcus Cumberbatch
Consultant Urological Surgeon from Sheffield
Information on transperineal biopsy, MRI-guided diagnosis, and prostate cancer assessment.
Mr Michael Wanis
Consultant Urological Surgeon from South London
Expert advice on prostate diagnostics, biopsy procedures, and treatment pathways.
Need more information?
Speak to our team
If you have questions about a transperineal prostate biopsy or would like to discuss your options, contact the Global Prostate Solutions team or your referring urologist for further guidance.